AustralieFrV1, Main, Exploration, bibRecord, 007813

Human fatality associated with Pacific ciguatoxin contaminated fish

Identifieur interne : 007813 ( Main/Exploration ); précédent : 007812; suivant : 007814

Human fatality associated with Pacific ciguatoxin contaminated fish

Auteurs : Brett Hamilton [Australie] ; Nigel Whittle [Australie] ; Glen Shaw [Australie] ; Geoff Eaglesham [Australie] ; Michael R. Moore [Australie] ; Richard J. Lewis [Australie]

Source :

Toxicon : (Oxford) [ 0041-0101 ] ; 2010.

RBID : Pascal:10-0488174

Descripteurs français

Pascal (Inist)
- Homme, Mort, Ciguatoxine, Pisces, Origine animale, Ciguatera, Intoxication, Spectrométrie masse, Milieu marin.
Wicri :
- topic : Homme, Mort, Milieu marin.

English descriptors

KwdEn :
- Animal origin, Ciguatera, Death, Human, Marine environment, Mass spectrometry, Pisces, Poisoning.

Abstract

Ciguatera is a food poisoning identified as the principal risk factor in the consumption of tropical fish in Oceania. The syndrome, which follows ingestion of ciguatoxin-contaminated ciguateric fishes, is characterised by an array of gastrointestinal and neurological features. In this report we examine forensic samples associated with a human fatality using a ³H-brevetoxin binding assay and reversed-phase HPLC/MS and HPLC/MS/MS. Three Pacific ciguatoxins (P-CTX) were detected in the implicated fish flesh sample by LC-MS/MS, implicating multiple P-CTXs in the fatal case. Additionally, ciguatoxin was identified in a liver sample obtained at post-mortem. The level of ciguatoxin detected (0.14 ppb P-CTX-1 equivalents by binding assay) indicated that at least 10% of the ingested P-CTX-1 remained in the human liver 6 days after the toxic fish was consumed. This study confirms the potential of tropical reef fish to accumulate sufficient P-CTX to be lethal to humans, especially if the liver and viscera are consumed as part of the meal.

Affiliations:

Australie

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002287
to stream PascalFrancis, to step Curation: 003D07
to stream PascalFrancis, to step Checkpoint: 002351
to stream Main, to step Merge: 007E19
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Le document en format XML

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<front><div type="abstract" xml:lang="en">Ciguatera is a food poisoning identified as the principal risk factor in the consumption of tropical fish in Oceania. The syndrome, which follows ingestion of ciguatoxin-contaminated ciguateric fishes, is characterised by an array of gastrointestinal and neurological features. In this report we examine forensic samples associated with a human fatality using a <sup>3</sup>
H-brevetoxin binding assay and reversed-phase HPLC/MS and HPLC/MS/MS. Three Pacific ciguatoxins (P-CTX) were detected in the implicated fish flesh sample by LC-MS/MS, implicating multiple P-CTXs in the fatal case. Additionally, ciguatoxin was identified in a liver sample obtained at post-mortem. The level of ciguatoxin detected (0.14 ppb P-CTX-1 equivalents by binding assay) indicated that at least 10% of the ingested P-CTX-1 remained in the human liver 6 days after the toxic fish was consumed. This study confirms the potential of tropical reef fish to accumulate sufficient P-CTX to be lethal to humans, especially if the liver and viscera are consumed as part of the meal.</div>
</front>
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Human fatality associated with Pacific ciguatoxin contaminated fish

Human fatality associated with Pacific ciguatoxin contaminated fish

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri